Disseminated giant hyperkeratotic porokeratosis and treatment with acitretin: a case report.

© 2015 The Authors. doi: 10.2340/00015555-1908 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Porokeratosis (PK) is a disorder of clonal hyperproliferation of keratinocytes. It has several clinical manifestations characterised by variably sized papules or plaques with a fine peripheral keratotic rim and central atrophy accompanied by a histological finding of cornoid lamella (1). Cutaneous lesions vary in their appearance and distribution. Disseminated superficial actinic porokeratosis (DSAP) is characterised by numerous papules and plaques distributed over sun-exposed sites. Coexistence of disseminated superficial and disseminated warty PK is very rare (2). A recent review on DSAP found no published controlled trials evaluating its treatment (3). The knowledge base for treatment is derived exclusively from case reports. To our knowledge, none of the published cases of disseminated superficial and warty PK describe the results of systemic treatment with acitretin.